Acrocanthosaurus is a four-star large carnivore in Jurassic Park: Operation Genesis. It is found in Hell Creek Formation A, along with Parasaurolophus and Torosaurus. Its favored prey is Parasaurolophus, even though Acrocanthosaurus was extinct long before Parasaurolophus evolved.
Arcocanthrosaurus is often used in carnivore dominance duels, in which the character playing the game pits two large carnivores against each other in a high-stakes fight over territory. Females, at least, are highly territorial. Acrocanthosaurus can coexist and become friendly with another 4-star carnivore, Carcharodontosaurus, as shown on its page. This may be because both Acrocanthosaurus and Carcharodontosaurus are carcharodontosaurids and thus quite similar. Interestingly, they do not hunt sauropods as much as they did in reality.