John Hammond died in 1998 and handed over InGen to Simon Masrani, who build Jurassic World. After the disaster in that park and the death of Masrani, unforeseen events started to manifest. Lockwood tries to deal with this blowback of what he and Hammond had done.
Lockwood meets with Claire Dearing about bringing the dinosaurs to a safe haven. He's shown to be sick throughout the movie. He's very protective of his granddaughter and won't let her see pictures of her mother. This is because he secretly cloned his daughter after she died, which resulted in Maisie Lockwood. He is smothered by Eli Mills after he finds out about Eli's secret agenda.